20 februari 2014 - Voortschrijdend inzicht: toch nu chemotherapie nemen?
Na mijn operatie was het advies van de AVL-werkgroep: geen chemo. Dat was ook mijn expliciete wens en hoop geweest; ik zou dan weer een tijd behandeling-vrij kunnen zijn, was mijn visie.
Maar denkend over mijn toekomst, over de samen met mijn arts te bepalen frequentie en wijze van vervolgcontroles (CA125, CT-scan), werd ik zeer onrustig van de gedachte dat er nu elders in mijn buik nog niet detecteerbare celdeling plaats vindt, die zich over een paar maanden plotseling en misschien wel fataal manifesteert... Dus waarom niet die cellen nu aangepakt en stil te leggen met chemotherapie? Natuurlijk weet ik wat de nadelen zijn, zowel van chemo, als van het nu nemen. Maar toch. Ik heb gebeld met de verpleegkundige oncologie die met mijn arts gaat overleggen. Ook heb ik aangegeven een andere internist hierover te willen spreken. Wordt vervolgd.
12 februari 2014 - Studiecentrum PB is weer open
Niet dat ik al volledig bed-af ben of 100% hersteld, maar het gaat de goede kant op.
Dus dient de onvermijdelijke vraag zich aan: hoe te leven in de fase waarin ik nu verkeer? Hoe mijn leven in te vullen?
Voor mij is het vanzelfsprekend een deel van mijn tijd nog steeds als medisch student te besteden. Ik lees over zelfheling, nieuwe medicijnen, bestudeer clinical trials, kruiden, etc. Ik blijf op zoek naar levensverlengende mogelijkheden.
Vandaag ben ik te rade gegaan bij een chinese arts in Amsterdam, heb ik mij geregistreerd als belangstellende voor experimentele medicijnen op de website www.myTomorrows.com, gisteren heb ik een zeer verrassend gesprek gehad bij Wim Huppes in Hilversum, www.stichtingruigerus.com
Posts tonen met het label chemotherapy. Alle posts tonen
Posts tonen met het label chemotherapy. Alle posts tonen
- Hot Cancer Cells Are Easier To Kill: New Drug Delivery System Uses Nanotechnology Heating To Kill 95 Percent Of Ovarian Cancer Cells
http://www.medicaldaily.com/hot-cancer-cells-are-easier-kill-new-drug-delivery-system-uses-nanotechnology-heating-kill-95-260246
By John Ericson | Oct 17, 2013 07:42 PM
When the cancer cells were heated to about 104 degrees, only 5 percent survived.
Heat may be the next big thing in ovarian cancer treatment. In a new study, researchers at Oregon State University have shown that a combination of heat and cytotoxic drugs delivered with nanotechnology can kill up to 95 percent of ovarian cancer cells. The discovery could inspire more effective treatments and prevention strategies for a disease that currently kills more than 150,000 women each year worldwide.
Published in The International Journal of Pharmaceutics, the study suggests that localized hyperthermia can improve the effect of traditional chemotherapy drugs by 65 percent. According to lead author Olena Taratula, such an improvement could have significant bearing on the prognosis in cases of ovarian cancer, in which chemotherapy is more or less inevitable. "Ovarian cancer is rarely detected early, and because of that chemotherapy is often needed in addition to surgery," Taratula said in a press release. "It's essential for the chemotherapy to be as effective as possible the first time it's used, and we believe this new approach should help with that."
The localized hyperthermia is made possible by an innovative drug delivery system based on nanotechnology. First, iron oxide nanoparticles are coated with a cytotoxic agent and delivered to cancer cells by a peptide. Once they are inside the sick cells, the nanoparticles are rapidly heated.
"The hyperthermia, or heating of cells, is done by subjecting the magnetic nanoparticles to an oscillating, or alternating magnetic field," co-author Pallavi Dhagat explained. "The nanoparticles absorb energy from the oscillating field and heat up." For the experiment, the team used the chemotherapy drug doxorubicin, which by itself would have left about 70 percent of the cancer cells alive. But when the cells were heated to about 104 degrees, only 5 percent survived.
"I'm very excited about this delivery system," Taratula said. "Cancer is always difficult to treat, and this should allow us to use lower levels of the toxic chemotherapeutic drugs, minimize side effects and the development of drug resistance, and still improve the efficacy of the treatment. We're not trying to kill the cell with heat, but using it to improve the function of the drug." That said, the new method is still in need of additional research. Animal tests and human trials must be completed before the finished product can be introduced to the market. Still, the researchers are confident that the new delivery system will improve the treatment of ovarian cancer as well as other elusive types of the disease.
Source: Olena Taratula, Raj Kumar Dani, Canan Schumann, Hong Xu, Andrew Wang, Han Song, Pallavi Dhagat, Oleh Taratula.Multifunctional nanomedicine platform for concurrent delivery of chemotherapeutic drugs and mild hyperthermia to ovarian cancer cells. International Journal of Pharmaceutics, 2013.
Published in The International Journal of Pharmaceutics, the study suggests that localized hyperthermia can improve the effect of traditional chemotherapy drugs by 65 percent. According to lead author Olena Taratula, such an improvement could have significant bearing on the prognosis in cases of ovarian cancer, in which chemotherapy is more or less inevitable. "Ovarian cancer is rarely detected early, and because of that chemotherapy is often needed in addition to surgery," Taratula said in a press release. "It's essential for the chemotherapy to be as effective as possible the first time it's used, and we believe this new approach should help with that."
The localized hyperthermia is made possible by an innovative drug delivery system based on nanotechnology. First, iron oxide nanoparticles are coated with a cytotoxic agent and delivered to cancer cells by a peptide. Once they are inside the sick cells, the nanoparticles are rapidly heated.
"The hyperthermia, or heating of cells, is done by subjecting the magnetic nanoparticles to an oscillating, or alternating magnetic field," co-author Pallavi Dhagat explained. "The nanoparticles absorb energy from the oscillating field and heat up." For the experiment, the team used the chemotherapy drug doxorubicin, which by itself would have left about 70 percent of the cancer cells alive. But when the cells were heated to about 104 degrees, only 5 percent survived.
"I'm very excited about this delivery system," Taratula said. "Cancer is always difficult to treat, and this should allow us to use lower levels of the toxic chemotherapeutic drugs, minimize side effects and the development of drug resistance, and still improve the efficacy of the treatment. We're not trying to kill the cell with heat, but using it to improve the function of the drug." That said, the new method is still in need of additional research. Animal tests and human trials must be completed before the finished product can be introduced to the market. Still, the researchers are confident that the new delivery system will improve the treatment of ovarian cancer as well as other elusive types of the disease.
Source: Olena Taratula, Raj Kumar Dani, Canan Schumann, Hong Xu, Andrew Wang, Han Song, Pallavi Dhagat, Oleh Taratula.Multifunctional nanomedicine platform for concurrent delivery of chemotherapeutic drugs and mild hyperthermia to ovarian cancer cells. International Journal of Pharmaceutics, 2013.
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